Principal Scientist: Pharmacologist

Principal Scientist: Pharmacologist

Principal Scientist: Pharmacologist

Location: Cambridge, UK
Start Date: Immediate preferred
Salary: Competitive compensation package including share options, subject to experience

Closing date: 3rd June 2019

Healx is a fast-growing Cambridge (UK) startup combining computational methods and deep pharmacology expertise to identify existing drugs that may treat rare diseases, enabling treatments to be found at a fraction of the time and cost of traditional drug discovery. There are over 7,000 rare diseases that affect an estimated 350 million people worldwide, most of which lack effective treatment. We work closely with patient groups and charities to understand clinical unmet need and with industry to help them find opportunities for progress in rare diseases.

We’re looking for a talented biochemist/pharmacologist with broad drug discovery expertise to lead the identification and translation of drug repurposing candidates. This is a key role reporting directly to the CSO with the opportunity to have a major impact during our next phase of growth.


The role

  • Lead the selection of drug candidate molecules from existing drugs (‘repurposed drugs’) based on deep knowledge of disease pathways, drug targets and mechanisms, and general biochemistry
  • Using your disease, drug and biochemistry knowledge, build a pharmacological rationale for potential drug repurposing candidates identified through Healx’s predictive methods.
  • Guide their translation through preclinical stages, providing in vitro / in vivo study design input
  • Write summary reports for client projects, and for internal projects, including chemical, biochemical, pharmacological, pharmaceutical, pharmacokinetic and medical properties to justify the selection of candidate drugs
  • Report directly to the CSO and engage with the Pharmacology Advisory Board to refine and finalise drug repurposing predictions
  • Work with bioinformaticians and software engineers developing algorithmic methods and tools, provide pharmacology input for new developments
  • Interact with clients (charities and pharmaceutical companies) on pharmacology matters
  • Work with CEO and Head of Business Development to generate and maintain long term relationships with Healx partners


Who we’re looking for

  • University Degree (with at least a 2:1) and postgraduate degree from a top university in Biochemistry / Pharmacology or related discipline
  • Minimum of 5 years of experience as a biochemist / pharmacologist in a pharmaceutical environment or related
  • In-depth knowledge of the drug discovery and drug development process from project startup to clinical trials
  • Able to demonstrate a strong understanding of disease biology applied to drug discovery ideally including in the oncology therapeutic area
  • Experience in drug repurposing desirable
  • Experience of pre-clinical study design
  • Experience in drug repurposing desirable
  • Human disease knowledge, ideally current oncology and neurology clinical practice


How to apply

Click on the apply button to submit your CV and covering letter. Please note, we will only review applications that are submitted using the link below.


Download Healx Rare Treatment Award application form