Healx scientists develop new ways of predicting disease relationships
Healx scientists, in a study led by Erin Oerton, have evaluated different types of biological information for their value of relating diseases to each in other, in a publication that has just appeared in the journal Bioinformatics.
The study took six different types of data sets into account, namely ontological, phenotypic, literature co-occurrence, genetic association, gene expression, and drug indication data, in order to create a ‘Disease Map’ of 84 diseases. The constructed map was able to re-create already established relationship between diseases, as well as to identify novel links between them.
Many of the novel links could be corroborated by clinical evidence, such as shared drugs that can be used to treat related diseases. Learnings from the study will be implemented for future use in Healnet, Healx’s unique AI-driven drug discovery platform for rare diseases.